Publications

Journal Title Author(s) Year of Publication
Phospholipid oxidation and carotenoid supplementation in Alzheimer's disease patients [ahead of print] Ademowo OS, Dias HK, Milic I, Dervitt A, Moran R, Mulcahy R, Howard AN, Nolan JM, Griffiths HR 2017
Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging. Feeney J, O'Leary N, Moran R, O'Halloran AM, Nolan JM, Beatty S, Young IS, Kenny RA. 2017
Serum and macular response to carotenoid-enriched egg supplementation in human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT) Kelly D, Nolan JM, Howard AN, Stack J, Akuffo KO, Moran R, Thurnham DI, Dennison J, Meagher KA, Beatty S 2017
The evidence informing the surgeon’s selection of intraocular lens on the basis of light transmittance properties Li X, Kelly D, Nolan JM, Dennison JL, Beatty S 2017
Author Response: Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1: Retina, 2016 John Nolan, Rebecca Power, Jim Stringham, Jessica Dennison, Jim Stack David Kelly, Rachel Moran, Kwadwo Akuffo, Laura Corcoran, S Beatty 2016
Bone and Landrum: Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1: Retina, 2016 Bone and Landrum 2016
Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1 John Nolan, Rebecca Power, Jim Stringham, Jessica Dennison, Jim Stack David Kelly, Rachel Moran, Kwadwo Akuffo, Laura Corcoran, S Beatty 2016
Quantification of zeaxanthin stereoisomers and lutein in trout flesh using chiral high-performance liquid chromatography-diode array detection Alfonso Prado-Cabrero, Stephen Beatty, Jim Stack, Alan Howard, John M. Nolan 2016
Macular Supplements Containing Zinc and Vitamin A Should Be Replaced with Meso-Zeaxanthin, Lutein and Zeaxanthin: An Ophthalmic Need for Pharmacovigilance Amber Hoang, Michael S Tolentino and Michael J Tolentino 2016
Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density Le Ma, Rong Liu, Jun Hui Du, Tao Liu, Shan Shan Wu and Xiao Hong Liu 2016
An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases Roxanne Crosby Nwaobi Philip Hykin Tunde Peto Sobha Sivaprasad 2016
Non-dietary correlates and determinants of plasma lutein and zeaxanthin concentrations in the Irish population R Moran, JM Nolan, J Stack, A.M O'Halloran, J Feeney, K.O Akuffo, R.A Kenny and S Beatty. 2016
Relationship between macular pigment and visual function in subjects with early age-related macular degeneration Kwadwo Owusu Akuffo, John M Nolan, Tunde Peto, Jim Stack, Irene Leung, Laura Corcoran, Stephen Beatty 2016
Antitumor activity of meso-zeaxanthine and its mechanism of action Firdous A. P., Binitha P. P, Girija Kuttan, Ramadasan Kuttan 2016
Lutein, zeaxanthin and meso-zeaxanthin content of eggs laid by hens supplemented with free and esterified xanthophylls John M. Nolan Katherine A. Meagher Alan N. Howard, Rachel Moran, David I. Thurnham and Stephen Beatty 2016
Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease Nicole K. Scripsema, Dan-Ning Hu and Richard B. Rosen 2015
Concordance of Macular Pigment Measurement Using Customized Heterochromatic Flicker Photometry and Fundus Autofluorescence in Age-Related Macular Degeneration Kwadwo Owusu Akuffo,Stephen Beatty, Jim Stack, Tunde Peto, Irene Leung, Laura Corcoran, Rebecca Power, and John M. Nolan 2015
Visual Function and Its Relationship with Severity of Early, and Activity of Neovascular, Age-Related Macular Degeneration. Loughman, S Sabour-Pickett, JM Nolan, B Klein, R Klein. J 2015
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease Bernstein PS, Li B, Vachali PP, Gorusupudi A, Shyam R, Henriksen BS, Nolan JM. 2015
Assessment of lutein, zeaxanthin and meso-zeaxanthin concentrations in dietary supplements by chiral high-performance liquid chromatography Alfonso Prado‑Cabrero, Stephen Beatty, Alan Howard, Jim Stack, Philipp Bettin, John M. Nolan 2015
Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids David Kelly Robert F. Coen, Kwadwo Owusu Akuffo, Stephen Beatty, Jessica Dennison, Rachel Moran, Jim Stack, Alan N. Howard, Riona Mulcahy an 2015
Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration KO Akuffo, JM Nolan, AN Howard, R Moran, J Stack, R Klein, BE Klein, SM Meuer, S Sabour-Pickett, DI Thurnham and S Beatty 2015
Anti-inflammatory potential of carotenoid meso-zeaxanthin and its mode of action. Firdous AP, Kuttan G, Kuttan R. 2015
Prevalence of age-related macular degeneration in the Republic of Ireland Kwadwo Owusu Akuffo,John Nolan, Jim Stack, Rachel Moran, Joanne Feeney, Rose Anne Kenny, Tunde Peto, Cara Dooley, Aisling M O’Halloran, Hila 2015
The Impact of Supplemental Macular Carotenoids in Alzheimer’s Disease: A Randomized Clinical Trial [ahead of print] Nolan JM, Loskutova E, Howard A, Mulcahy R, Moran R, Stack J, Bolger M, Coen RF, Dennison J, Akuffo KO, Owens N, Power R, Thurnham D, Beatty 2014
Regarding Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration Meagher KA, Nolan JM, Beatty, S. 2014
Macular Response to supplementation with differing xanthophyll formulations in subjects with and without age related macular degeneration Thurnham DI, Nolan JM, Howard AN, Beatty S 2014
Verification of Meso-Zeaxanthin in Fish Nolan JM, Beatty S, Meagher K, Howard AN, Kelly D, Thurnham DI 2014
Supplementation with three different macular carotenoid formulations inpatients with early age-related macular degeneration Sabour-Pickett S1, Beatty S, Connolly E, Loughman J, Stack J, Howard A, Klein R, Klein BE, Meuer SM, Myers CE, Akuffo KO, Nolan JM 2014
Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials. Akuffo KO1, Beatty S, Stack J, Dennison J, O'Regan S, Meagher KA, Peto T, Nolan J. 2014
Macular Pigment, Visual Function, and Macular Disease among Subjects with Alzheimer's Disease: An Exploratory Study John Nolan Nolan JM, Loskutova E, Howard AN, Moran R, Mulcahy R, Stack J, Bolger M, Dennison J, Akuffo KO, Owens N, Thurnham DI, Beatty S 2014
Syngene Toxicology Capabilities Syngene International Limited (Sponsored by IOSA) 2014
Syngene Corporate Presentation Syngene International Limited (Sponsored by IOSA) 2014
90-Day Repeated Dose Toxicity Study of 40:60 Diacetate Lutein: Diacetate Meso-Zeaxanthin by Oral Gavage in Sprague Dawley Rats Syngene International Limited (Sponsored by IOSA) 2014
Evidence for Including Lutein and Zeaxanthin in Oral Supplements for Age Related Macular Degeneration Musch DC 2013
AREDS2: what does it mean for eye care? Nolan JM, Beatty S, Stack J 2013
Secondary Analyses of the Effects of Lutein/Zeaxanthin on Age Related Macular Degeneration Progression The Age-Related Eye Disease Study 2 (AREDS2) Research 2013
LuteinZeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration. The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial The Age-Related Eye Disease Study 2 (AREDS2) Research Group* 2013
Enhancing Performance While Avoiding Damage: A Contribution of Macular Pigment Stringham J and Snodderly M 2013
Studies on meso-zeaxanthin for potential toxicity and mutagenicity Thurnham, D and Howard AN 2013
Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action Alikkunjhi Pararikkal Firdousa, Edakkadath Raghavan Sindhua, Viswanathan Ramnathb & Ramadasan Kuttan 2013
Macular Pigment and Its Contribution to Vision Ekaterina Loskutova, John Nolan, Alan Howard and Stephen Beatty 2013
What is meso-zeaxanthin, and where does it come from? J M Nolan, K Meagher, S Kashani and S Beatty 2013
Safety evaluation of meso-zeaxanthin Xinde Xu , Lihua Zhang, Bin Shao, Xiaoxia Sun, Chi-Tang Ho, Shiming Li b 2013
Nutrient reference values for bioactives: new approaches needed? A conference report Hans Konrad Biesalski, John W. Erdman, Jr., John Hathcock,corresponding author Kathleen Ellwood, Stephen Beatty, Elizabeth Johnson, Roberto 2013
Achieving visual excellence through optimization of macular pigment Kashani, S, Nolan , JM and Beatty. S 2013
Impact of Macular Pigment on Visual Performance Dennison, J, Nolan, JM, Beatty, S and O'Regan, G 2012
Secondary Outcomes in a Clinical Trial of Carotenoids with Coantioxidants versus Placebo in Early Age-Related Macular Degeneration Beatty S, Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, Stevenson MR 2012
Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxannthin Nolan J, Beatty S 2012
Impact of dietary carotenoid deprivation on macular pigment and serum concentrations of lutein and zeaxanthin Loughman J, Nolan JM, Beatty S. 2012
Education Is Positively Associated with Macular Pigment: The Irish Longitudinal Study on Ageing (TILDA) Nolan JM, Feeney J, Kenny RA, Cronin H, O'Regan C, Savva GM, Loughman J, Finucane C, Connolly E, Meagher K, Beatty S. 2012
The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Loughman J, Nolan JM, Howard AN, Connolly E, Meagher K, Beatty S 2012
Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM 2012
Amelioration of radiation induced damages in mice by carotenoid meso -zeaxanthin Alikkunjhi Pararikkal Firdous , Edakkadath Raghavan Sindhu , Viswanathan Ramnath and Ramadasan Kuttan 2012
Influence of the dietary carotenoids lutein and zeaxanthin on visual performance: application to baseball Hammond BR and Fletcher LM 2012
Lutein, zeaxanthin, meso-zeaxanthin content in egg yolk and their absence in fish and seafood Rasmussen HM, Muzhingi, T, Eggert, E.R, Johnson, EJ 2012
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment Nolan JM, AkkalI MC, Loughman J, Howard A, Beatty S. 2012
A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. Sabour-Pickett S, Nolan JM, Loughman J, Beatty S. 2012
Supplementation with all three macular carotenoids: response, stability and safety Connolly, E.E, Beatty, S, Loughman, J, Howard, A, Louw, M, Nolan, JM 2011
Macular pigment and its contribution to visual performance and experience James Loughmana,*, Peter A. Davisona, John M. Nolanb, M.C. Akkalib, Stephen Beattyb 2010
26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition Biesalski HK, J Aggett P, Anton R, Bernstein PS, Blumberg J, Heaney RP, Henry J, Nolan JM, Richardson DP, van Ommen B, Witkamp RF, Rijkers G 2010
Macular pigment optical density in an ageing Irish population: The Irish Longitudinal Study on Ageing. Nolan JM, Kenny R, O'Regan C, et al. 2010
Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study Connolly EE, Beatty S, Thurnham DI, et al 2010
A central dip in the macular pigment spatial profile is associated with age and smoking Kirby ML, Beatty S, Loane E, et al 2010
Studies on the singlet oxygen scavenging mechanism of human macular pigment Li B, Ahmed F, Bernstein PS 2010
Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products Perry A, Rasmussen H, Johnson EJ 2009
The rationale and evidence base for a protective role of macular pigment in age-related maculopathy Loane E, Kelliher C, Beatty S, Nolan JM 2008
A supplementation study in human subjects with a combination of meso-zeaxanthin, (3R,3'R)-zeaxanthin and (3R,3'R,6'R)-lutein. Thurnham DI, Tremel A, Howard AN. 2008
A review of dietary sources and bioavailability and some relationships with macular pigment optical Thurnham DI 2007
Risk factors for age-related maculopathy are associated with a relative lack of macular pigment. Nolan JM, Stack J, O' DO, Loane E, Beatty S. 2007
Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula Bhosale P, Zhao dY, Serban B, Bernstein PS 2007
Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin Bone RA, Landrum JT, Cao Y, Howard AN, varez-Calderon F 2007
Salmonella-Escherichia coli/Mammalian-microsome reverse mutation assay with a confirmatory assay with mesozeaxanthin Mecchi MS 2006
Thirteen-week oral (gavage) toxicity of mesozeaxanthin in Han Wistar rats with a 4-week recovery Chang CJG 2006
Synergistic effects of zeaxanthin and its binding protein in the prevention of lipid membrane oxidation Bhosale P, Bernstein PS 2005
Nutritional manipulation of primate retinas, III: effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys Johnson EJ, Neuringer M, Russell RM, Schalch W, Snodderly DM 2005
Identification and Characterization of a Pi Isoform of Glutathione S-Transferase (GSTP1) as a Zeaxanthin-binding Protein in the Macula of the Human Eye. Bhosale P, Larson AJ, Frederick JM, Southwick K, Thulin CD, Bernstein PS 2004
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Kassoff A, The AREDS research group 2001
Stereochemistry of the Human Macular Carotenoids Bone RA, Landrum JT, Hime GW, Cains A, Zamor J 1993
The first isolation of enantiomeric and meso-zeaxanthin in nature Maoka T, Arai A, Shimizu M, Matsuno T 1986
The Macular Pigment .1. Absorbance Spectra, Localization, and Discrimination from Other Yellow Pigments in Primate Retinas Snodderly DM, Brown PK, Delori FC, Auran JD 1984
OPTOMETRY PUBLICATIONS
Introduction of a Toric Intraocular Lens to a Non-Refractive Cataract Practice: Challenges and Outcomes Clare Kirwan, John M Nolan, Jim Stack, Ian Dooley, Johnny Moore, Tara CB Moore, and Stephen Beatty 2016
The Impact of Cataract, and Its Surgical Removal, on Measures of Macular Pigment Using the Heidelberg Spectralis HRAþOCT MultiColor Device Kwadwo Owusu Akuffo, John M. Nolan, Jim Stack, Rebecca Power, Clare Kirwan, Rachel Moran,Laura Corcoran,Niamh Owens,and Stephen Beatty 2016
The eye-health diet Nolan J, Withers, N 2012
Impact of macular pigment on visual performance Dennison J, Nolan JM, Beatty S, O'Regan G 2012
Effect of Lutein and Zeaxanthin on Macular Pigment and Visual Function in Patients with Early Age-Related Macular Degeneration Le Ma, MD, Shao-Fang Yan, MD, Yang-Mu Huang, MD, Xin-Rong Lu, MsC Fang Qian, MsC, Hong-Lei Pang, MsC, Xian-Rong Xu, MD, Zhi-Yong Zou, MD, Pe 2012
The Heritability of Macular Response to Supplemental Lutein and Zeaxanthin: a Classical Twin Study. Hammond CJ, Liew SM, Van Kuijk FJ, Beatty S, Nolan JM, Spector TD, Gilbert C 2012
Targeting AMD with a Critical Carotenoid Bone R, Landrum J, Beatty S, Nolan JM 2011
Dietary macular carotenoid supplements and drusen resolution Asif F, Nolan JM 2011
Online AMD Research Study for Optometrists: Current Practice in the Republic of Ireland and the UK Loughman J, Nolan JM, Stack J, Beatty S. 2011
Macular supplements Loane E, Nolan JM, Baranyovits P, Akkali M, Beatty S 2009
Identifying and managing risk of AMD Nolan JM, Beatty S, O'Regan G 2008
Impact of macular pigment on visual performance Loughman J, Davison P, Nolan JM, Beatty S 2007
Macular pigment and its putative protective effect for ARM Kirby M, Loane E, Nolan JM, Beatty S 2007